Price : $1.00 jack
28-11-17 0 Hits

Product Name:SR9011 CAS NO.:1379686-29-9 Molecular Formula:C23H31ClN4O3S Molecular Weight:479.03524 Purity:99% Appearance:White Powder Grade:Pharmaceutical Grade SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

>http://985671628.global-trade-center.com

288# Xinfeng Road,Jianggan District,Hangzhou,Zhejiang,China


Send Message Phone: 13385818498

Related ads

Buy U-47700 Crystal online at good rates

U-47700 is an opioid sedative research chemical developed by a team at Upjohn in the 1970s. U-47700 was derived from an earlier opioid AH-7921. U-47700 is selective for the µ-opioid receptor, having around 7.5 x the potency of morphine in animal models…

Sell MDMA MDPV BK-ebdp methylone ethylone alprazolam skype:hbmilin888

email:sales2@hbmilin.com  skype:hbmilin888  whatsapp:+8617153058087  Product advantage  1. We can guarantee the quality of the product.  2. Fast and safe delivery .  3. We can provide competitive price for you. The more you buy , the lower the price will…

powerful mantra 9878377317 ALL vashikaran ,Black magic specialist tantrik

+919878377317 VASHIKARAN SPECIALIST TANTRIK VISHAWNATH JI. Tantrik vishawnath is the most experienced and world reputed astrologer in India. अब घर बेठे पाए अपने जीवन की जटिल समस्या का समाधान Edhar udhar na bhatke kyunki aap ki samsya ka samadhan hamare…

DRUGS ONLINE PAINKILLERS, ROXICODONE, NORCO 10/325, KETAMINE, OXYCONTIN, XANAX 2MG BARS, DILUADID, METHADONE

Mandrax(Quaalude),Nembutal,Klonopin Ativan Dilaudid AMBIEN Oxycontin Percocet Roxicodone ETC contact us with your order Call/text/Whatsapp us : +1-(727) 201-1822 Send Email:---- tropicpharma3 @gmail.com---------…

DRUGS ONLINE PAINKILLERS, ROXICODONE, NORCO 10/325, KETAMINE, OXYCONTIN, XANAX 2MG BARS, DILUADID, METHADONE

Mandrax(Quaalude),Nembutal,Klonopin Ativan Dilaudid AMBIEN Oxycontin Percocet Roxicodone ETC contact us with your order Call/text/Whatsapp us : +1-(727) 201-1822 Send Email:---- tropicpharma3 @gmail.com---------…

Report this ad