Price : $1.00 Emma
26-07-17 0 Hits

Methylone Methylene Methylon Methylone crystal Methylone (also known as "3,4-methylenedioxy-N-methylcathinone", "MDMC", "βk-MDMA" and by the slang term "M1") is an empathogen and stimulant psychoactive drug. It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes. Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group.[2] Methylone was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant.[3] Starting around 2004, methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries. Resemblance to MDMA[edit] See also: MDMA Structural similarities between some amphetamine-like stimulants and their 3,4-methylenedioxy- derivatives. Left: amphetamine, methamphetamineand methcathinone. Right: MDA, MDMA, and methylone Methylone substitutes for MDMA in rats trained to discriminate MDMA from saline. Methylone does not substitute for amphetamine or for the hallucinogenic DOM in animals trained to discriminate between these drugs and saline.[4] Further, also in common with MDMA, methylone acts on monoaminergic systems. In vitro, methylone has one third the potency of MDMA at inhibiting platelet serotonin accumulation and about the same in its inhibiting effects on the dopamine and noradrenaline transporters.[5][6][2] In spite of these behavioral and pharmacological similarities between methylone and MDMA, the observed subjective effects of both drugs are not completely identical. Alexander Shulgin wrote of the former:[7] "[Methylone] has almost the same potency of MDMA, but it does not produce the same effects. It has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA." Pharmacology[edit] Pharmacodynamics[edit] Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine.[2][8] In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine anddopamine transporters is similar.[2][8] Notably, methylone's affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA.[2] The results of these differences in pharmacology relative to MDMA are that methylone is lesspotent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone has relatively robust releasing capabilities,[8] perhaps due to its ability to phosphorylate the monoamine transporters being similar in potency relative to MDMA.[citation needed] Pharmacokinetics[edit] The two major metabolic pathways in mammals for methylone are N-demethylation to methylenedioxycathinone (MDC), and demethylation followed by O-methylation of the 3- or 4-hydroxy group to 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC). When 5 mg/kg of methylone was administered to rats, it was found that around 26% was excreted as HMMC within the first 48 hours (less than 3% excreted unchanged).[9]

>http://www.hmbiological.com/

Hebei


Send Message Phone: +86 15694876274

Related ads

Buy Namenda (Memantine) 10mg online.

Namenda (Memantine) treats dementia (memory loss and mental changes) that is a sign of Alzheimer’s disease. You can buy Namenda (Memantine) 10mg tablets online without prescription (No RX). product price is as: per pill Minimum order quantity is: 50 pills…

BUEF/buef/direct Factory cheaper Price.High PurityCAS NO.: 132465-11-3

Main products: BK-EBDP; 5F-ADB; FUB-AMB; HEXEN/Hexedrone, NM2201; 4-CEC; 4F-PHP; 4C-PVP; U4770; BUEF;HJH Place of Origin: Hubei,China Application:reaserch chemical MOQ: 10gram Purity: > 99.7% Package: Paluminum foil bag or as request Storage: Dry and cool…

FOR SALE ACTAVIS,HYDROCODON,OXYCODONE,XANAX +1(240)532-2986

PLEASE READ: Why Us ? 1-Shipping secure and discreet ,Delivery time -24 hours depending on your location 2-tracking number provided for your shipment (Fast,safe and reliable delivery) 3-with or without scripts 4-packing is highly discreet sealed, wrapped…

Buy XANAX, Xanax, PERCOCETS,Oxys,Opana,Roxycodone online

 Our online pharmacy will supply you to your door step with our pain relief meds, antidepressants, anxiety meds, stimulant drugs, narcoleptic, ecstasy pills, weight loss and other medication. With us, your order is safe and handle by professionals, quick…

offer dibutylone dibu bk-ebdp bkebdp crystal chemical from manufacturer supplier

e-mail: susan@njzcpharma.com skype: susanchem33 Are you in search of good RCs? Do you want to find a stable supplier? We are Nanjing Zhongceng Industry Co.,Ltd, specialized in pharmaceutical intermediates like: Product catalog 4cec 4cdc 4emc fuef…

Report this ad